What is the role of GFAP?
What is the role of GFAP?
The GFAP gene provides instructions for making a protein called glial fibrillary acidic protein. This protein is a member of the intermediate filament family of proteins. Intermediate filaments form networks that provide support and strength to cells.
Which cells are GFAP-positive?
GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci. 2006 Apr;31(4):676-84.
What is GFAP in astrocytes?
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease.
Where is glial fibrillary acidic protein found?
Glial fibrillary acidic protein (GFAP) is an intermediate filament-III protein uniquely found in astrocytes in the CNS, non-myelinating Schwann cells in the PNS and enteric glial cells. GFAP mRNA expressions are regulated by several nuclear-receptor hormones, growth factors and lipopolysaccharides.
Is GFAP expressed in all astrocytes?
Numerous studies have demonstrated an increased amount of GFAP in reactive astrocytes in different types of lesions or in cultured astrocytes [4,5,6]. Secondly, it has become clear that not all astrocytes in vivo express GFAP, or only weakly so [6,7,8,9,10].
Do all astrocytes have GFAP?
What cells does GFAP stain?
GFAP is known to be present in non-myelinating Schwann cells in the PNS, and the enteric glia cells as part of the enteric nervous system (ENS) [2,3].
Do microglia express GFAP?
Our results indicate that microglia more likely gave rise to AbA cells expressing astrocytic markers in regions adjacent to motor neurons. The finding that spinal AbA cells co-express astrocytic GFAP with two different microglia markers Iba1 or CD163 was surprising because such a mixed phenotype is rarely observed.
Is GFAP a marker of microglia?
Glial fibrillary acidic protein (GFAP) is one of the major intermediate filament proteins in mature astrocytes and is used to distinguish astrocytes from other glial cells (e.g. oligodendrocytes and microglia).
What are GFAP positive astrocytes?
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is expressed in glial cells (astrocytes) and increased GFAP immunoreactivity (or astrocytic activation) is usually viewed as an index of gliosis or a relatively slow-developing correlate of neural damage (Finch, 2003; Hausmann, 2003).
Are all astrocytes GFAP positive?
Is GFAP specific to astrocytes?
Glial fibrillary acidic protein (GFAP) is expressed exclusively in astrocytes in the central nervous system.
Does GFAP stain all astrocytes?
However, GFAP is not an absolute marker of all non-reactive astrocytes and is often not immunohistochemically detectable in astrocytes in healthy CNS tissue or remote from CNS lesions (Figs.