What is amifostine used for?

What is amifostine used for?

Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer.

When do you give amifostine?

Amifostine is given by intravenous (into a vein) infusion. The treatment is given before radiation or chemotherapy starts. Patients are given the infusion while lying down and their blood pressure is monitored frequently. Patients may be asked to increase their fluid intake for 24 hours before the infusion.

Is amifostine FDA approved?

Amifostine Trial Represents First FDA Approval of Treatment Interacting With Radiation.

What type of drug is amifostine?

OrganothiophosphateAmifostine / Classification

What is toxic mucositis?

Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for cancer.

Is amifostine still used?

Based upon these findings, amifostine was approved for use as a radiation protection agent by the FDA for the reduction of xerostomia in pa- tients receiving postoperative head and neck radiation therapy. Till today, amifostine remains the first and only radiation protector that is FDA approved for clinical use.

What class of drug is amifostine?

Is amikacin a strong antibiotic?

Amikacin is most often used for treating severe infections with multidrug-resistant, aerobic Gram-negative bacteria, especially Pseudomonas, Acinetobacter, Enterobacter, E. coli, Proteus, Klebsiella, and Serratia. The only Gram-positive bacteria that amikacin strongly affects are Staphylococcus and Nocardia.

What is the fastest way to cure mucositis?


  1. brush your teeth with a soft toothbrush at least twice a day.
  2. gently floss once a day if you can.
  3. rinse your mouth with warm water (or water mixed with a bit of salt) several times a day.
  4. suck on crushed ice or ice lollies.
  5. eat soft, moist foods, like soup, jelly or soft fruit, or try adding gravy or sauces to meals.

Can mucositis cause death?

Oral mucositis is a frequent and devastating side effect of anticancer treatments. It impairs the patient’s quality of life and also can be life threatening because severe infections and delayed or incomplete anticancer treatments may result.

Why amikacin is given once daily?

For elderly patients a smaller dose of amikacin than the regular daily dose of 15 mg/kg bw, i.e. about 11 mg/kg bw, seems recommendable, when it is given once daily. From the data obtained it is also obvious that once-daily dosing of amikacin does not eliminate the need for checking serum concentrations of the drug.

What foods to avoid with mucositis?

Foods to avoid

  • Rough-textured or hard foods.
  • Tart, acidic or salty foods.
  • Spicy foods.
  • Really warm foods or drinks.
  • Crackers and hard-crust breads.
  • Potato chips, pretzels, popcorn and snack chips.
  • Citrus fruit and juices.
  • Tomato juice.

Is mucositis serious?

Mucositis is when your mouth or gut is sore and inflamed. It’s a common side effect of chemotherapy and radiotherapy for cancer. Although mucositis is usually painful, it can be treated. It should get better within a few weeks of finishing cancer treatment.

Is amikacin safe in liver disease?

Amikacin as well as other aminoglycosides are not mentioned in large case series of drug induced liver disease and acute liver failure; thus, hepatic injury due to amikacin is very rare if it occurs at all. Likelihood score: E (unlikely cause of clinically apparent liver injury).

How many days amikacin should be taken?

Descriptions. Amikacin injection is used to treat serious bacterial infections in many different parts of the body. This medicine is for short-term use only (7 to 10 days). Amikacin belongs to the class of medicines known as aminoglycoside antibiotics.

What drinks help mouth ulcers?

Drink cold fluids, such as water or iced tea, or eat Popsicles. Sometimes fluid touching the canker sore can cause a stinging pain. Use a straw so the fluid doesn’t touch the canker sore. Hold ice on the canker sore until it is numb.

How can I permanently get rid of mouth ulcers?

Treatment options for mouth ulcers include:

  1. Avoid spicy and sour foods until the ulcers heal.
  2. Drink plenty of fluids.
  3. Keep your mouth clean.
  4. Apply antiseptic gel to the ulcers.
  5. Regularly rinse your mouth out with warm, slightly salted water, keeping the rinse in your mouth for up to 4 minutes at a time.

What foods make mouth ulcers worse?


  • do not eat very spicy, salty or acidic food.
  • do not eat rough, crunchy food, such as toast or crisps.
  • do not drink very hot or acidic drinks, such as fruit juice.
  • do not use chewing gum.
  • do not use toothpaste containing sodium lauryl sulphate.

What lack of vitamin causes mouth ulcers?

When you don’t receive enough vitamin B12, your body produces abnormally large red blood cells that don’t function correctly. Vitamin B12 deficiency is often associated with anaemia, and it can cause symptoms that include mouth ulcers.