What does ochronosis mean?
Ochronosis is the bluish-black discoloration of certain tissues, such as the ear cartilage and the ocular tissue, seen with alkaptonuria, a metabolic disorder.
What causes ochronosis?
Disease at a Glance Ochronosis associated with alkaptonuria is caused by a genetic change in the HGD gene, which results in the accumulation and deposition of homogentisic acid (HGA) in cartilage. The affected tissue becomes weak and brittle with time, leading to chronic inflammation, joint pain, and osteoarthritis.
What is Ochronotic arthropathy?
Ochronotic arthropathy is the musculoskeletal manifestation of alkaptonuria. an uncommon inherited metabolic disorder associated with various clinical and radiologic abnormalities due to the deposition of homogentisic acid.
How does osteoarthritis cause ochronosis?
When the urine with HA is exposed to oxygen it darkens, this dark urine is characteristically seen in ochronosis. Secondary osteoarthritis is a primary symptom that typically first presents itself in the lower back. The osteoarthritis is caused by increased accumulation of pigment in the cartilage.
Is ochronosis permanent?
Comment. Exogenous ochronosis-like pigmentation, may occur after the topical application of hydroquinone, is limited to sites of application. The hyperpigmentation may fade slightly after discontinuing the agent, but the discoloration is usually permanent.
What is exogenous ochronosis?
Exogenous ochronosis (EO) is a cutaneous disorder characterized by blue-black pigmentation resulting as a complication of long-term application of skin-lightening creams containing hydroquinone but may also occur due to topical contact with phenol or resorcinol in dark-skinned individuals.
What is the best treatment for ochronosis?
Ochronotic arthropathy is treated with physiotherapy, analgesia, rest, and prosthetic joint replacement when necessary. Exogenous ochronosis caused by topical hydroquinone use has been treated successfully with picosecond laser.
What is exogenous Ochronosis?
What does arthropathy mean in medical terms?
Arthropathy is a joint disease, of which arthritis is a type. Arthropathies can be associated with a hematologic (blood) disorder or an infection, such as Lyme disease.
What causes exogenous Ochronosis?
Synopsis. Exogenous ochronosis is the brown-black skin discoloration that occurs as a result of dermal accumulation of homogentisic acid. The most common cause of exogenous ochronosis is application of topical hydroquinone as part of the formulation in a variety of skin bleaching creams.
How long does it take for ochronosis?
Exogenous ochronosis from topical hydroquinone occurs most frequently in individuals with skin phototypes IV-VI, but individuals with lighter skin phototypes may be affected as well. Onset has been reported as soon as 6 months of use.
Can you treat ochronosis?
Exogenous ochronosis has been largely refractory to topical agents, whereas clinical improvement has been reported after treatment with physical modalities such as dermabrasion, CO 2, and Q-switched 755-nm alexandrite laser irradiation. However, the condition remains difficult to treat.
What is the difference between arthritis and arthropathy?
Arthritis is a form of arthropathy that involves inflammation of one or more joints, while the term arthropathy may be used regardless of whether there is inflammation or not. Joint diseases can be classified as follows: Arthritis.
Is massage good for facet joint pain?
Massage is an excellent tool for relieving pain caused by facet joint problems. It can greatly release muscle tension as well as stimulating blood flow to the area. In particular, those who suffer from painful muscle spasms from facet joint problems can reap great rewards.