Is cisplatin used in breast cancer?

Is cisplatin used in breast cancer?

Cisplatin is widely used to treat solid tumors, including breast, testicular, and ovarian cancers [7]. Cisplatin exerts its anticancer effects by inducing DNA double-strand breaks (DSBs) [8, 9]. Despite a consistent initial response, cisplatin treatment results in the development of chemoresistance.

Can cisplatin be given before gemcitabine?

Recently, we described that the schedule in which cisplatin was administered 24 hours before gemcitabine produced the best pharmacological profile. Based on this and because toxicity was manageable, the schedule cisplatin 24 hours prior to gemcitabine was chosen for phase II evaluation.

Does gemcitabine and cisplatin cause hair loss?

Flu-like symptoms of muscle pain, fever, headache, chills and fatigue. Rash. Hair loss. Muscle weakness.

How effective is gemcitabine?

Since 1997, gemcitabine therapy has been the standard first-line treatment for patients with unresectable locally advanced or metastatic pancreatic cancer. Among patients with metastatic disease, the 5-year survival rate is only 2%,1 and 1-year survival rates of 17 to 23% have been reported with gemcitabine.

Is cisplatin a strong chemo?

Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].

Is gemcitabine well tolerated?

Conclusion: Gemcitabine plus cisplatin overall is a reasonably well-tolerated treatment regimen for patients aged ≥ 65 years. The results of the present study support the use of a lower gemcitabine dose of 1000 mg/m(2), because it was better tolerated.

When does gemcitabine side effects start?

The following side effects are common (occurring in more than 30%) for patients taking Gemcitabine: Flu-like symptoms(muscle pain, fever, headache, chills, fatigue) Fever (within 6-12 hours of first dose)

Do you lose your hair with gemcitabine?

You could lose all your hair. This includes your eyelashes, eyebrows, underarm, leg and sometimes pubic hair. Your hair will usually grow back once treatment has finished but it is likely to be softer. It may grow back a different colour or be curlier than before.

How toxic is gemcitabine?

Gemcitabine is associated with a wide spectrum of lung toxicities, ranging from dyspnea 25% of patients to severe pulmonary toxicity in up to 5% of patients.

How long is gemcitabine infusion?

The recommended dose of gemcitabine is 1000 mg/m2, given by 30-minute intravenous infusion. This should be repeated once weekly for up to 7 weeks followed by a week of rest.

Does gemcitabine cause lung problems?