How do you give an Eptoin injection?

How do you give an Eptoin injection?

Phenytoin Injection BP should be injected slowly and directly into a large vein through a large-gauge needle or intravenous catheter. It must be administered slowly. Intravenous administration should not exceed 50 mg/minute in adults.

How do you dilute phenytoin for infusion?

For administration by intravenous infusion phenytoin injection should be diluted in 50 – 100 ml of normal saline, and the final concentration of phenytoin in the solution should not exceed 10 mg/ml, the infusion mixture should not be refrigerated.

Can you give phenytoin IV push?

Pediatrics: A loading dose of 15-20 mg/kg of Dilantin intravenously will usually produce plasma concentrations of phenytoin within the generally accepted therapeutic range (10 20 mcg/mL). The drug should be injected slowly intravenously at a rate not exceeding 1 3 mg/kg/min or 50 mg per minute, whichever is slower.

Can phenytoin be given IM?

When administered intramuscularly, phenytoin is poorly absorbed and can cause hemorrhagic necrosis of the soft tissues at the injection site. Many of these side effects can be avoided in children with the use of fosphenytoin.

Can phenytoin be injected?

Phenytoin injection is used to control certain types of seizures (convulsions) in the treatment of epilepsy. It is also used to prevent and treat seizures that occur during brain surgery. This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

How do you give phenytoin 100mg IV?

Phenytoin IV administration

  1. Give phenytoin over 30-40 minutes (rate <50mg/minute).
  2. Ideally, administer undiluted via a syringe pump through a large gauge needle or IV catheter into a large forearm vein.

What IV fluid is compatible with phenytoin?

It is concluded that 0.9% sodium chloride and lactated Ringer’s injections are suitable diluents for the intravenous administration of phenytoin.

Can phenytoin be mixed with dextrose?

If administered in diluted form, parenteral phenytoin should be diluted with normal saline. Parenteral phenytoin should not be added to dextrose or dextrose-containing solutions due to the potential for precipitation.

Can phenytoin be given undiluted?

Phenytoin IV administration Ideally, administer undiluted via a syringe pump through a large gauge needle or IV catheter into a large forearm vein. If dilution is essential, mix with 100–250ml sodium chloride 0.9% to a final concentration of <10mg/ml, and administer by infusion pump.

Is Eptoin and phenytoin same?

Eptoin tablet is also used for the prevention of seizures (fits) during brain-related surgery. It contains phenytoin as its active ingredient.

Can phenytoin be crushed?

Do not crush or chew. Take this medicine with food if it upsets your stomach. It may be best to take your medicine consistently with or without food. Take your doses at regular intervals.

How do you load phenytoin?

Is phenytoin compatible with dextrose?

The concentration of phenytoin declined rapidly in all dextrose solutions but at different rates for each brand. A greater stability was demonstrated when phenytoin was diluted in 0.9% sodium chloride and lactated Ringer’s injections.

What IV solution is not compatible with phenytoin?

Parenteral phenytoin should not be added to dextrose or dextrose-containing solutions due to the potential for precipitation. Because of the risk of local toxicity, IV phenytoin should be administered directly into a large peripheral or central vein through a large-gauge catheter.

What is Eptoin used for?

Eptoin Tablet is a prescription medicine used to treat and prevent epilepsy (seizures). It controls seizures by decreasing the abnormal and excessive activity of the nerve cells in the brain.

What is Eptoin level?

Although the reference range is between 10 and 20 µg/mL, about half of patients’ seizures are controlled at values lower and higher than the therapeutic range. Some adverse effects of phenytoin are related to specific serum levels. Nystagmus is frequently observed at levels greater than 20 µg/mL.

Is phenytoin compatible with tube feeding?

Food and drug interactions If your child receives tube feedings with such a product, give the phenytoin at least 1 hour before or 2 hours after feeding. If your child receives continuous tube feedings, stop the tube feedings for 1 hour before giving the medicine.

Can phenytoin be given via NG tube?

Nonionized phenytoin is irreversibly bound to NG tubing from solution at the pH of enteral nutrient solutions while this is not the case for anionic phenytoin in unbuffered water or saline.

Why does IV phenytoin need a filter?

RE: Administration of intravenous IV phenytoin injection In addition, due to its low aqueous solubility, dilution in sodium chloride 0.9% gives an increased risk of precipitate formation in the infusion bag, thus requiring the use of an inline filter during administration.

How fast can you push phenytoin?

The drug should be injected slowly intravenously at a rate not exceeding 1-3 mg/kg/min or 50 mg per minute, whichever is slower. Continuous monitoring of the electrocardiogram and blood pressure is essential.